You always read "you can't get enough of X nutrient in your diet!", but looking behind the curtain we've found a few caveats to that statement. Below is a list of nutrients we've researched.

To fully understand your unique reaction to any supplement we recommend the following: Request extensive blood work from a local lab (or online) and test your DNA. With the results, consult your knowledgable practition in order to have a meaninful discussion about your current health state and any predispositions you may have.

To read more, click here for Ryan's or Jacob's complete supplement list for health, longevity and exercise performance.


Copper - you get enough in your diet, regardless of a good or bad diet

  • Associated with aging, neurological disease, cancer, Alzheimer’s [1][2]
  • No supplementation recommended

Iron - you get enough in your diet from animal products

  • Associated with sickness, infections, accelerated aging, Alzheimer’s [1][3]
  • No supplementation recommended (unless blood work shows Ferritin levels under 20 ng/ml and you don't want to eat animal products)

Manganese - you get enough from any western diet and even breathing

  • Associated with Parkinson’s, Alzheimer’s, limiting dopamine [4][5][6]
  • No supplementation recommended, 100%DV found in Pure O.N.E

Vitamin E - daily multi-vitamin typically contains enough

  • Very high doses associated with prostate cancer and all cause mortality [7][8]
  • Do not intake very high or mega doses, 100%DV found in Pure O.N.E

Folic acid - also known as B9, not found in food

  • Mixed studies on cancer, heart disease, and all cause mortality
  • No supplementation recommended (MTHFR mutations and methylation issues should try folinic acid or MTHF)

Omega-3 - the most important fatty acid in the omega 3-6-9 group, you can always use more

  • No known risks of over-consuming omega 3s (DHA, EPA, ALA)
  • Supplement to improve your Omega ratio aim for a 1:1 ratio of 6:3 [9][10]
  • Note: The average Inuit person in Greenland eats about 13,000 mg of Omega-3 per day benefiting their longevity compared to the western diet person.

Omega-6 - you may over-consume Omega 6 fatty acid (FA, AA) vs Omega 3 from your current diet, the average US diet is >10:1 ratio

  • A high western diet style Omega 6:3 ratio has shown to increase risk of cardiovascular disease, cancer, and inflammatory and autoimmune diseases [9][10][11]
  • No supplementation recommended, beware of consuming canola, corn, safflower, sunflower, grapeseed oils that are very high in omega 6 fatty acid

Omega-9 - unlike omega 3 and 6, your body can make omega 9 (OA, EA, GA, +) and all diets provide enough O9

  • Omega-9 is linked to better organ functionality and associated with decreased risk of all cause mortality, further research is needed on O9. Studies show most beneficial ratio of Omega 9:6:3 to be low:medium:high.
  • No supplementation recommended

References